INTRATUMORAL T-CELL AND B-CELL RECEPTOR ARCHITECTURE ASSOCIATES WITH DISTINCT IMMUNE TUMOR MICROENVIRONMENT FEATURES AND CLINICAL OUTCOMES OF ANTI-PD-1/L1 IMMUNOTHERAPY

Background Effective cooperation between B-cells and T-cells within the tumor microenvironment may lead to the regression of established tumors.B-cells and T-cells can recognize tumor antigens with exquisite specificity via their receptor complexes.Nevertheless, whether a diverse intratumoral B-cells and T-cell receptor (BCR, TCR) repertoire affect

The paper, based on the coordinates of the problems triggered by the negative externalities chain generated by the poor food supply and production system at the level of the urban collectivities, carries out an analysis focused on the identification of the tools, mechanisms, and good practices needed to ensure the sustainability of the local polici